賴伯亮 醫師

Po-Liang Lai

脊椎側彎矯正專家

脊椎側彎矯正

賴伯亮醫師目前擔任林口長庚醫院骨科部脊椎科主任，以及骨骼關節研究中心主任。賴伯亮醫師畢業於台灣大學醫學系，自民國八十二年進入長庚醫院服務，完成骨科專科醫師訓練後，擔任本院骨科部脊椎科主治醫師迄今。期間曾至美國鳳凰城向Dr. Anthony Yeung學習微創脊椎手術，回國後推廣內視鏡椎間盤治療的觀念。民國90年得到Dr. Hansen Yuan的首肯，在美國紐約上城醫學院醫院任一年的脊椎研究員，回國後即開始研究脊椎融合後生物力學的變化，獲得骨科醫學會優秀論文獎。民國91年8月至韓國首爾向石世一教授學習脊椎側彎的矯正手術，之後成為國內全骨釘立體矯正脊椎側彎的先驅，爾後多次擔任脊椎側彎相關研討會的座長或手術示範醫師。服務病患的時間之餘，在清華大學完成化學工程博士學位，研究生物醫學材料的骨科學應用。

賴醫師專致於脊椎外科手術，涵蓋微創脊椎手術和困難的脊椎側彎矯正手術，每年約進行400台脊椎相關手術，臨床及基礎研究均有傑出表現，超過120篇論文發表，獲得許多獎勵，包括第12屆國家新創獎。


專長

脊椎側彎矯正


手術量

脊椎側彎手術：共約 600 例 (至2015年)

脊椎側彎手術：每年約 40 例

其他脊椎手術：每年約 200 例


賴伯亮醫師 - 脊椎側彎治療介紹

學歷

台灣大學醫學系


經歷

林口長庚醫院骨科暨外科住院醫師

美國紐約上城醫學院研究醫師

林口長庚骨科部脊椎科主治醫師

台灣脊椎外科醫學會監事


現任

林口長庚醫院骨科部脊椎科教授

長庚大學醫學系教授

PUBLICATIONS

  1. Chen CH, Lai PL, Niu CC, Chen WJ, Shih CH*: Anterior dislocation of the shoulder and ipsilateral humberal shaft fracture : Case reports and literature review. Journal of Orthopaedic Surgery Taiwan 1997; 14(3): 232-236.
  2. Chen CH, Lai PL, Niu CC, Chen WJ, Shih CH*: Simultaneous anterior dislocation of the shoulder and fracture of the ipsilateral humeral shaft. Two case reports. International Orthopaedics 1998; 22(1): 65-67. (SCI；IF:2.019；Orthopedics 22/67)
  3. Lai PL, Yang WE*, Chen WJ, Lin PY: Gouty os trigonum tarsi : case report. Chang Gung Medical Journal 1998; 21(4): 509-513.
  4. Tu YK*, Ueng SW, Lai PL, et al.: The current trend of orthopedic microsurgery applied in trauma and emergency department. Journal of Critical care Medicine ROC 1999; 10(2): 47-54.
  5. Chen WJ*, Lai PL, Niu CC, Chen LH, Fu TS, Wong CB: Surgical treatment of adjacent instability after lumbar spine fusion. Spine 2001; 26(22): E519-524. (SCI；IF:2.447；Orthopedics 15/67)
  6. Chen WJ*, Lai PL, Chang CH, Lee MS, Chen CH, Tai CL: The effect of hyperbaric oxygen therapy on spinal fusion: using the model of posterolateral intertransverse fusion in rabbits. Journal of Trauma-Injury Infection & Critical Care 2002; 52(2): 333-338. (SCI；IF:2.961；Surgery 30/202)
  7. Chen WJ*, Wu CC, Jung CH, Chen LH, Niu CC, Lai PL: Combined anterior and posterior surgeries in the treatment of spinal tuberculous spondylitis. Clinical Orthopaedics and Related Research 2002(398): 50-59. (SCI；IF:2.882；Orthopedics 8/67)
  8. Wong CB, Chen WJ*, Chen LH, Niu CC, Lai PL: Clinical outcomes of revision lumbar spinal surgery: 124 patients with a minimum of two years of follow-up. Chang Gung Medical Journal 2002; 25(3): 175-182.
  9. Fu TS, Wong CB, Lai PL, Niu CH, Chen LH, Chen WJ*: Feasibility of computer-assisted fluoroscopic navigation of pedicle screw insertion. Journal of Orthopaedic Surgery Taiwan 2003; 20(3): 118-123.
  10. Tsai TT, Chen WJ*, Lai PL, Chen LH, Niu CC, Fu TS, Wong CB: Polymethylmethacrylate cement dislodgment following percutaneous vertebroplasty: a case report. Spine 2003; 28(22): E457-460. (SCI；IF:2.447；Orthopedics 15/67)
  11. Chen WJ*, Lai PL, Chen LH: Adjacent instability after instrumented lumbar fusion. Chang Gung Medical Journal 2003; 26(11): 792-798.
  12. Chen LH*, Lai PL, Niu CC, Chen CH, Chen WJ, Fu TS: Intracorporal bone grafting for vertebral compression fractures with intraosseous vacuum phenomenon. International Orthopaedics 2004; 28(1): 52-55. (SC I；IF:2.019；Orthopedics 22/67)
  13. Chen LH*, Chang CH, Lee ZL, Niu CC, Lai PL, Tan CF, Chen WJ: Intervertebral disc herniation in adolescents. Chang Gung Medical Journal 2004; 27(1): 22-28.
  14. Chen LH*, Niu CC, Yu SW, Fu TS, Lai PL, Chen WJ: Minimally invasive treatment of osteoporotic vertebral compression fracture. Chang Gung Medical Journal 2004; 27(4): 261-267.
  15. Huang JJ, Niu CC*, Chen LH, Lai PL, Fu TS, Chen WJ: Anterior cervical spinal surgery for multi-level cervical myelopathy. Chang Gung Medical Journal 2004; 27(7): 531-541.
  16. Chen WJ, Lai PL* (corresponding), Tai CL, Chen LH, Niu CC: The effect of sagittal alignment on adjacent joint mobility after lumbar instrumentation--a biomechanical study of lumbar vertebrae in a porcine model. Clinical Biomechanics 2004; 19(8): 763-768. (SCI；IF:1.880；Orthopedics 27/67)
  17. Lai PL* (corresponding), Chen LH, Niu CC, Chen WJ: Effect of postoperative lumbar sagittal alignment on the development of adjacent instability. Journal of Spinal Disorders & Techniques 2004; 17(5): 353-357. (SCI；IF:1.888；Orthopedics 26/67)
  18. Lai PL, Chen LH*, Niu CC, Fu TS, Chen WJ: Relation between laminectomy and development of adjacent segment instability after lumbar fusion with pedicle fixation. Spine 2004; 29(22): 2527-2532. (SC I；IF:2.447；Orthopedics 15/67)
  19. Chen LH*, Niu CC, Fu TS, Lai PL, Wong CB, Chen WJ: Posterior decompression and stabilization for metastatic spine diseases. Chang Gung Medical Journal 2004; 27(12): 903-910.
  20. Fu TS, Chen LH, Wong CB, Lai PL, Tsai TT, Niu CC, Chen WJ*: Computer-assisted fluoroscopic navigation of pedicle screw insertion: an in vivo feasibility study. Acta Orthopaedica Scandinavica 2004; 75(6): 730-735. (SCI；IF:2.452；Orthopedics 14/67)
  21. Chen LH*, Niu CC, Lai PL, Fu TS, Chen WJ: Recurrent giant cell tumor of the thoracic spine with bilateral pulmonary metastases. Journal of the Formosan Medical Association 2004; 103(12): 957-961. (SCI；IF:1.695；Medicine, General & Internal 57/150)
  22. Fu TS, Chen LH, Liao JC, Lai PL, Niu CC, Chen WJ*: Magnetic resonance imaging characteristics of benign and malignant vertebral fractures. Chang Gung Medical Journal 2004; 27(11): 808-815.
  23. Kao FC, Niu CC*, Chen LH, Lai PL, Chen WJ: Maintenance of interbody space in one- and two-level anterior cervical interbody fusion: comparison of the effectiveness of autograft, allograft, and cage. Clinical Orthopaedics and Related Research 2005(430): 108-116. (SCI；IF:2.882；Orthopedics 8/67)
  24. Chen LH, Kao FC, Niu CC, Lai PL, Fu TS, Chen WJ*: Surgical treatment of spinal pseudoarthrosis in ankylosing spondylitis. Chang Gung Medical Journal 2005; 28(9): 621-628.
  25. Niu CC*, Chen LH, Lai PL, Fu TS, Chen WJ: Single cylindrical threaded cage used in recurrent lumbar disc herniation. Journal of Spinal Disorders & Techniques 2005; 18: S65-S72. (SCI；IF:1.888；Orthopedics 26/67)
  26. Chen LH, Lai PL*(corresponding), Chen WJ: Unipedicle percutaneous vertebroplasty for spinal intraosseous vacuum cleft. Clinical Orthopaedics and Related Research 2005(435): 148-153. (SCI；IF:2.882；Orthopedics 8/67)
  27. Niu CC*, Chen LH, Lai PL, Fu TS, Chen WJ: Trapezoidal titanium cage in anterior cervical interbody fusion: a clinical experience. Chang Gung Medical Journal 2005; 28(4): 212-221.
  28. Lai PL, Lui TN, Jung SM, Chen WJ*: Spinal ganglioneuroma mimicking adolescent idiopathic scoliosis. Pediatric Neurosurgery 2005; 41(4): 216-219. (SCI；IF:0.497；Surgery 181/202)
  29. Wu KP, Lai PL, Lee LF, Hsu CC*: Autonomic dysreflexia triggered by an unstable lumbar spine in a quadriplegic patient (Case Reports). Chang Gung Medical Journal 2005; 28(7): 508-511.
  30. Fu TS, Lai PL, Tsai TT, Niu CC, Chen LH*, Chen WJ: Long-term results of disc excision for recurrent lumbar disc herniation with or without posterolateral fusion. Spine 2005; 30(24): 2830-2834. (SCI；IF:2.447；Orthopedics 15/67)
  31. Lai PL, Leu HS, Niu CC, Chen WJ, Chen LH*: Pyogenic spondylitis presenting with skip lesions. Chang Gung Medical Journal 2005; 28(9): 651-656.
  32. Chen WJ*, Tsai TT, Chen LH, Niu CC, Lai PL, Fu TS, McCarthy K: The fusion rate of calcium sulfate with local autograft bone compared with autologous iliac bone graft for instrumented short-segment spinal fusion. Spine 2005; 30(20): 2293-2297. (SCI；IF:2.447；Orthopedics 15/67)
  33. Yang SC, Fu TS*, Lai PL, Niu CC, Chen LH, Chen WJ: Transforaminal epidural steroid injection for discectomy candidates：An outcome study with a minimum of two-year follow-up. Chang Gung Medical Journal 2006; 29(1): 93-99.
  34. Yang SC, Chen LH*, Fu TS, Lai PL, Niu CC, Chen WJ: Surgical treatment for giant cell tumor of the thoracolumbar spine. Chang Gung Medical Journal 2006; 29(1): 71-78.
  35. Liu CL, Lai PL, Jung SM, Liao CC*: Thoracic ossified meningioma and osteoporotic burst fracture: treatment with combined vertebroplasty and laminectomy without instrumentation: case report. Journal of Neurosurgery : Spine 2006; 4(3): 256-259. (SCI；IF:2.355；Surgery 54/202)
  36. Chen LH, Lai PL, Tai CL, Niu CC, Fu TS, Chen WJ*: The effect of interspinous ligament integrity on adjacent segment instability after lumbar instrumentation and laminectomy--an experimental study in porcine model. Biomedical Materials and Engineering 2006; 16(4): 261-267. (SCI；IF:0.847；Engineering, Biomedical 62/77)
  37. Liao JC, Chen WJ*, Lai PL, Chen LH: Surgical treatment of achondroplasia with thoracolumbar kyphosis and spinal stenosis--a case report. Acta Orthopaedica 2006; 77(3): 541-544. (SCI；IF:2.452；Orthopedics 14/67)
  38. Lai PL*(corresponding): Delayed massive pleural effusion after scoliosis correction and thoracoplasty: A case report. Journal of Trauma-Injury Infection & Critical Care 2006; 61(3): 746-748. (SCI；IF:2.961；Surgery 30/202)
  39. Yang SC, Fu TS*, Chen LH, Niu CC, Lai PL, Chen WJ: Percutaneous endoscopic discectomy and drainage for infectious spondylitis. International Orthopaedics 2007; 31(3): 367-373. (SCI；IF:2.019；Orthopedics 22/67)
  40. Chen LH, Lai PL*, Lo YP, Fu TS, Niu CC, Chen WJ: Strategy to handle the complications of vertebroplasty for osteoporotic compression fracture. Journal of Orthopaedic Surgery Taiwan 2007; 24(2): 35-41.
  41. Tsai TT, Fu TS, Lai PL, Niu CC, Chen LH*, Chen WJ: Elucidating the roles of inflammatory cytokines in stimulation of sciatic pain in lumbar disc herniation. Journal of Orthopaedic Surgery Taiwan 2007; 24(2): 42-46.
  42. Chen LH*, Yang SC, Niu CC, Lai PL, Chen WJ: Percutaneous drainage followed by antibiotic-impregnated cement vertebroplasty for pyogenic vertebral osteomyelitis: a case report. Journal of Trauma-Injury Infection & Critical Care 2008; 64(1): E8-11. (SCI；IF:2.961；Surgery 30/202)
  43. Wu CH, Kao YH, Yang SC, Fu TS, Lai PL, Chen WJ*: Supplementary pedicle screw fixation in spinal fusion for degenerative spondylolisthesis in patients aged 65 and over: outcome after a minimum of 2 years follow-up in 82 patients. Acta Orthopaedica 2008; 79(1): 67-73. (SCI；IF:2.452；Orthopedics 14/67)
  44. Tai CL, Hsieh PH, Chen WP, Chen LH, Chen WJ, Lai PL* (corresponding): Biomechanical comparison of lumbar spine instability between laminectomy and bilateral laminotomy for spinal stenosis syndrome - an experimental study in porcine model. BMC Musculoskeletal Disorders 2008; 9: 84. (SCI；IF:1.898；Orthopedics 25/67)
  45. Chen WC, Chen WJ, Niu CC, Lai PL, Chen LH*: Percutaneous vertebroplasty using calcium sulfate cement for osteoporotic vertebral compression fractures with vacuum cleft. Journal of Orthopaedic Surgery Taiwan 2008; 25(4): 156-164.
  46. Lo YP, Chen WJ*, Chen LH, Lai PL: New vertebral fracture after vertebroplasty. Journal of Trauma-Injury Infection & Critical Care 2008; 65(6): 1439-1445. (SCI；IF:2.961；Surgery 30/202)
  47. Kao FC, Tu YK*, Lai PL, Yu SW, Yen CY, Chou MC: Inferior vena cava syndrome following percutaneous vertebroplasty with polymethylmethacrylate. Spine 2008; 33(10): E329-333. (SCI；IF:2.447；Orthopedics 15/67)
  48. Chang SS, Fu TS*, Liang YC, Lai PL, Niu CC, Chen LH, Chen WJ: Results of microendoscopic discectomy performed in the 26 case with a minimum 3 years follow-up. Chang Gung Medical Journal 2009; 32(1): 89-97.
  49. Niu CC*, Lai PL, Fu TS, Chen LH, Chen WJ: Ruling out piriformis syndrome before diagnosing lumbar radiculopathy. Chang Gung Medical Journal 2009; 32(2): 182-187.
  50. Chen LH*, Tai CL, Lai PL, Lee DM, Tsai TT, Fu TS, Niu CC, Chen WJ: Pullout strength for cannulated pedicle screws with bone cement augmentation in severely osteoporotic bone: influences of radial hole and pilot hole tapping. Clinical Biomechanics 2009; 24(8): 613-618. (SCI；IF:1.880；Orthopedics 27/67)
  51. Chen WJ*, Huang JW, Niu CC, Chen LH, Yuan LJ, Lai PL, Yang CY, Lin SS: Use of fluorescence labeled mesenchymal stem cells in pluronic F127 and porous hydroxyapatite as a bone substitute for posterolateral spinal fusion. Journal of Orthopaedic Research 2009; 27(12): 1631-1636. (SCI；IF:2.972；Orthopedics 6/67)
  52. Niu CC, Tsai TT, Fu TS, Lai PL, Chen LH, Chen WJ*: A comparison of posterolateral lumbar fusion comparing autograft, autogenous laminectomy bone with bone marrow aspirate, and calcium sulphate with bone marrow aspirate: a prospective randomized study. Spine 2009; 34(25): 2715-2719. (SCI；IF:2.447；Orthopedics 15/67)
  53. Chen CC*, Chen WJ, Chen LH, Chen WC, Lai PL: Management of complications after posterior lumbar interbody fusion with cages and posterior instrumentation: report of seven cases. Journal of Orthopaedic Surgery Taiwan 2009; 26(3): 137-143.
  54. Fu TS*, Yang SC, Tsai TT, Chen LH, Lai PL, Niu CC, Chen WJ: Percutaneous endoscopic debridement and drainage in immunocompromised patients with complicated infectious spondylitis. Minimally Invasive Therapy and Allied Technologies 2010; 19(1): 42-47. (SCI；IF:1.180；Surgery 126/202)
  55. Hung WH, Niu CC, Lai PL, Fu TS, Tsai TT, Wong CB, Yu CW, Chen LH*, Chen WJ: Minimal invasive treatment : Percutaneous vertebroplasty for metastatic spinal tumors. Journal of Orthopaedic Surgery Taiwan 2010; 27(1): 21-27.
  56. Chen LH*, Fu TS, Kao YH, Tsai TT, Lai PL, Niu CC, Chen WJ: Surgical treatment of infectious spondylitis in patients undergoing hemodialysis therapy. European Spine Journal 2010; 19(12): 2223-2228. (SCI；IF:2.800；Orthopedics 11/67)
  57. Niu CC, Yuan LJ, Chen LH, Lin SS, Tsai TT, Liao JC, Lai PL, Chen WJ*: Beneficial effects of hyperbaric oxygen on human degenerated intervertebral disk cells via suppression of IL-1β and p38 MAPK signal. Journal of Orthopaedic Research 2011; 29(1): 14-19. (SCI；IF:2.972；Orthopedics 6/67)
  58. Chen LH, Tai CL*, Lee DM, Lai PL, Lee YC, Niu CC, Chen WJ: Pullout strength of pedicle screws with cement augmentation in severe osteoporosis: a comparative study between cannulated screws with cement injection and solid screws with cement pre-filling. BMC Musculoskeletal Disorders 2011; 12: 33. (SCI；IF:1.898；Orthopedics 25/67)
  59. Chen LH*, Hsieh MK, Liao JC, Lai PL, Niu CC, Fu TS, Tsai TT, Chen WJ: Repeated percutaneous vertebroplasty for refracture of cemented vertebrae. Archives of Orthopaedic and Trauma Surgery 2011; 131(7): 927-933. (SCI；IF:1.310；Orthopedics 38/67)
  60. Hsieh MK, Chen LH, Niu CC, Fu TS, Lai PL, Chen WJ*: Postoperative anterior spondylodiscitis after posterior pedicle screw instrumentation. The Spine Journal 2011; 11(1): 24-29. (SCI；IF:2.800；Orthopedics 11/67)
  61. Yu YH, Chen WJ*, Chen LH, Niu CC, Fu TS, Lai PL: Posterior instrumented lumbar spinal surgery in uremic patients under maintenance hemodialysis. Spine 2011; 36(8): 660-666. (SCI；IF:2.447；Orthopedics 15/67)
  62. Chen LH*, Liao JC, Chen WJ, Lai PL, Keorochana G: Low-intensity pulsed ultrasound enhances healing of laminectomy chip bone grafts on spinal fusion: a model of posterolateral intertransverse fusion in rabbits. Journal of Trauma-Injury Infection & Critical Care 2011; 70(4): 863-869. (SCI；IF:2.961；Surgery 30/202)
  63. Lai PL, Tai CL*, Chen LH, Nien NY: Cement leakage causes potential thermal injury in vertebroplasty. BMC Musculoskeletal Disorders 2011; 12: 116. (SCI；IF:1.898；Orthopedics 25/67) CMRPG381301
  64. Tsai CF, Lai PL, Wong AMK, Chen CK*: Effectiveness of the Osaka medical college brace for the treatment of idiopathic scoliosis : a 1-year outcome analysis. Taiwan Journal of Physical Medicine & Rehabilitation 2011; 39(1):9-16.
  65. Chen LH*, Lai PL, Chen WJ: Current status of vertebroplasty for osteoporotic compression fracture. Chang Gung Medical Journal 2011;34:352-9.
  66. Fan Chiang CY, Niu CC＊, Lu ML, Lai PL, Chen LH, Chen WJ: Treating C1-2 subluxation with transarticular screw and posterior atlantoaxial fusion－A 5-year experience. Formosan Journal of Musculoskeletal Disorders. Vol. 2: 125-130, Nov. 2011.
  67. Chen LH＊, Hsieh MK, Niu CC, Fu TS, Lai PL, Chen WJ: Percutaneous vertebroplasty for pathological vertebral compression fractures secondary to multiple myeloma. Archives of Orthopaedic and Tramua Surgery, Vol.132:759-764, 2012. (SCI；IF:1.310；Orthopedics 38/67)
  68. Lai PL, Tai CL＊, Chu IM, Fu TS, Chen LH, Chen WJ: Hypothermic manipulation of bone cement can extend the handling time during vertebroplasty. BMC Musculoskeletal Disorders 2012; 13:198 (SCI; IF: 1.898; Orthopedics 25/67) CMRPG381301
  69. Fan Chiang CY, Tsai TT ＊, Chen LH, Lai PL, Fu TS, Niu CC, Chen WJ: Computed tomography-based navigation-assisted pedicle screw insertion for thoracic and lumbar spine fractures. Chang Gung Med J, Vol. 35(4):332-338, 2012 July-August.
  70. Lai PL, Hong DW, Lin Carl TY, Chen LH , Chen WJ, Chu IM*: Effect of mixing ceramics with a thermosensitive biodegradable hydrogel as composite graft. Composites Part B: Engineering Vol.43: 3088-3095, Dec. 2012. (SCI; IF:2.602; Engineering, multidisciplinary 7/87) CMRPG390121
  71. Lai PL, Hsu CC, Liu TH, Hong DW, Chen LH, Chen WJ, Chu IM*: Mixed micelles from methoxy poly(ethylene glycol)–polylactide and methoxy poly(ethylene glycol)–poly(sebacic anhydride) copolymers as drug carriers. Reactive & Functional Polymers , Vol.72: 846-855, Nov. 2012. (SCI; IF:2.822; Engineering, Chemical 20/133)
  72. Niu CC, Lin SS, Yuan LJ, Chen LH, Wang IC, Tsai TT, Lai PL, Chen WJ＊: Hyperbaric oxygen treatment suppresses MAPK signaling and mitochondrial apoptotic pathway in degenerated human intervertebral disc cells. Journal of Orthopaedic Research. 31(2): 204~209. Feb. 2013. (SCI；IF:2.972；Orthopedics 6/67)
  73. Lai PL, Hong DW, Liu TH, Lai ZT, Cheng MH, Chen LH, Chen WJ, Chu IM*: Validity of Poly(1, 6-bis-(p-carboxyphenoxy hexane)-co-(sebacicanhydride)) Copolymer in Biomedical Application. Journal of Applied Polymer Science. Vol. 128(6):3687-3695. June, 2013.(SCI; IF 1.640; Polymer science 38/82) CMRPG3B0481
  74. Lai PL*(corresponding), Lin TY, Hong DW, Yang SR, Chang YH, Chen LH, Chen WJ, Chu IM: Development of bioactive thermosensitive polymer-ceramic composite as bone substitute.Chemical Engineering Science. Vol.89: 133-141. Feb. 2013. (SCI；IF:2.613；Engineering, chemical 24/133) CMRPG3B0541
  75. Lai PL*, Hong DW, Chu IM, Chen WJ, Chen LH, Niu CC, Fu TS, Tsai TT, Liao JC: Polyanhydride copolymer and bioceramic composites as bone Substitutes. Formosan Journal of Musculoskeletal Disorders, Vol.4: 6-10, 2013. CMRPG3B0481
  76. Lu ML, Tsai TT(co-first author), Chen LH, Lai PL, Fu TS, Niu CC, Chen WJ*: Comparison of Fusion Rates between Autologous Iliac Bone Graft and Calcium Sulfate with Laminectomy Bone Chips in Multilevel Posterolateral Spine Fusion. Open Journal of Orthopedics. Vol. 3 No. 2, Page:119-127,2013.
  77. Tsai TT, Lai PL, Liao JC, Fu TS, Niu CC, Chen LH, Lee MS, Chen WJ, Fang HC, Ho NY, Pang JH＊: Increased periostin gene expression in degenerative intervertebral disc cells. Spine J. Vol.13(3):289-298, Mar. 2013. (SCI；IF:2.800；Orthopedics 11/67)
  78. Liao JC＊, Chen WJ, Chen LH, Niu CC, Fu TS, Lai PL, Tsai TT: Complications associated with instrumented lumbar surgery in patients with liver cirrhosis: a matched cohort analysis. Spine J. Vol.13(8):908-913, Aug. 2013. (SCI；IF:2.800；Orthopedics 11/67)
  79. Kao FC, Chen LH *, Lai PL, Fu TS, Tsai TT, Yu CW, Chen WC, Lu ML, Hsieh MK, Niu CC, Chen WJ: Clinical and radiographic outcome of pillow reduction prior to vertebroplasty on patients with vertebral compression fracture. Formosan Journal of Musculoskeletal Disorders. Vol.4(2):33-37, May, 2013.
  80. Lai PL*(corresponding), Chen LH, Chen WJ, Chu IM: Chemical and physical properties of bone cement for vertebroplasty. Biomedical Journal. Vol.36(4):162-167, Jul-Aug, 2013.
  81. Lin TY, Liao JC＊, Chen WJ, Chen LH, Niu CC, Fu TS, Lai PL, Tsai TT: Surgical risks and perioperative complications of instrumented lumbar surgery in patients with liver cirrhosis. Biomedical Journal. Vol.37(1):18-23, Jan-Feb, 2014.
  82. Hong DW, Lai ZT, Fu TS, Tsai TT, Chu IM* , Lai PL*(Co-corresponding): The influences of polycaprolactone-grafted nanoparticles on the properties of polycaprolactone composites with enhanced Osteoconductivity. Composites Science and Technology.Vol.83: 64-71. June, 2013. (SCI；IF:3.633；Materials science, composites 1/23) CMRPG3C0251
  83. Hong DW, Lai PL(Co-first author), Ku KL, Lai ZT, Chu IM*: Biodegradable in situ gel-forming controlled vancomycin delivery system based on a thermosensitive mPEG-PLCPPA hydrogel. Polymer Degradation and Stability. Vol.98(9):1578-1585. Sep. 2013. (SCI；IF:2.633；Polymer Science 22/82) CMRPG3B0542
  84. Lai PL, Hong DW, Ku KL, Lai ZT, Chu IM＊: Novel thermosensitive hydrogels based on methoxy polyethylene glycolco-poly(lactic acid-co-aromatic anhydride) for cefazolin delivery. Nanomedicine: Nanotechnology, Biology and Medicine. Vol.10: 553-560, 2014. (SCI；IF:5.978；Medicine, research & experimental 12/122). CMRPG3B0542
  85. Yu CW, Hsieh MK, Chen LH＊, Niu CC, Fu TS, Lai PL, Chen WJ, Chen WC, Lu ML: Percutaneous balloon kyphoplasty for the treatment of vertebral compression fractures. BMC surgery, Vol.14:3, 2014. (SCI；IF:1.240；Surgery 116/202)
  86. Tsai TT, Ho YJ Natalie, Lin YT, Lai PL, Fu TS, Niu CC, Chen LH, Chen WJ, S JH Pang＊: Advanced glycation end products in degenerative nucleus pulposus with diabetes. Journal of Orthopaedic Research. Vol.32(2) :238-244, Feb. 2014. (SCI；IF:2.972；Orthopedics 6/67)
  87. Kao FC, Lai PL*(corresponding), Chang C.H., Tsai TT, Fu TS, Niu CC, Chen LH, Chen WJ: Influence of lumbar curvature and rotation on forward flexibility in idiopathic scoliosis. Biomed J. Vol.37(2):78-83, March-Apirl, 2014. NSC 99-2314-B-182A-011
  88. Lin TY, Chen WJ, Hsieh MK, Lu ML, Tsai TT, Lai PL, Fu TS, Niu CC*, Chen LH: Postoperative meningitis after spinal surgery: a review of 21 cases from 20,178 patients. BMC Infectious Diseases. Vol.14:220, 2014. (SCI；IF:2.561；Infectious diseases 35/70)
  89. Niu CC, Lin SS, Yuan LJ, Chen LH, Pan TL, Yang CY, Lai PL, Chen WJ*: Identification of mesenchymal stem cells and osteogenic factors in bone marrow aspirate and peripheral blood for spinal fusion by flow cytometry and proteomic analysis. Journal of Orthopaedic Surgery and Research. Vol.9:32, 2014. (SCI；IF:1.577；Orthopedics 34/67)
  90. Tai CL, Chen LH, Lee DM, Liu MY, Lai PL*(corresponding): Biomechanical comparison of different combinations of hook and screw in one spine motion unit - an experiment in porcine model. BMC Musculoskeletal Disorders. Vol.15:197, 2014. (SCI；IF: 1.898；Orthopedics 25/67) CMRPD280021, CMRPD280022
  91. Lu ML, Tsai TT, Lai PL, Fu TS, Niu CC, Chen LH*, Chen WJ: A retrospective study of treating thoracolumbar spine fractures in ankylosing spondylitis. Eur J Orthop Surg Traumatol. Vol.24 Suppl 1:S117-S123. Jul. 2014.
  92. Peng YS, Lai PL(Co-first author), Peng Sydney, Wu HC, Yu S, Tseng TY, Wang LF＊, Chu IM: Glial cell line-dervied neurotrophic factor gene delivery via a polyethylene imine grafted chitosan carrier. International Journal of Nanomedicine. Vol.9:3163-3174. 2014. (SCI；IF:4.195；Nanoscience & nanotechnology 21/73) CMRPG3C0101
  93. Kao FC, Thapa Suresh Bahadur, Lu ML, Tsai TT＊, Lai P.L., Niu CC, Chen LH, Chen WJ: Costotransversectomy approach for treatment of thoracic spine infection. Formosan Journal of Musculoskeletal Disorders. Vol.5:59-67, 2014.
  94. Lin CY, Lai PL, Chuang SY, Ju DT, Chiang CJ, Chen WP＊: The biomechanical effects of cement augmentation and partial vertebral height restoration on the load transfer change of adjacent vertebrae in vertebroplasty. Journal Mechanics in Medicine and Biology.Vol.15(3):1550025, 2014.
  95. Chang MP, Tsung YC, Hsu HC, Tuan WH, Lai PL: Addition of a small amount of glass to improve the degradation behavior of calcium sulfate bioceramic. Ceramics International. Vol.41:1155-1162, 2014.(SCI)
  96. Tsai TT, Cheng CM*, Chen CF, Lai PL: Mechanotransduction in Intervertebral Discs. Journal of Cellular and Molecular Medicine. Vol.18(12):2351-2360, Dec. 2014. (SCI ) (SCI；IF=3.698；Medicine Research & Experimental 27/122) NSC 100-2314-B-182-059/CMRPG3D0671(Review Article)
  97. Lin TY, Tsai TT*, Lu ML, Niu CC, Hsieh MK, Fu TS, Lai PL, Chen LH, Chen WJ: Comparison of two-stage open versus percutaneous pedicle screw fixation in treating pyogenic spondylodiscitis. BMC Musculoskeletal Disorders. Vol.15:443, 2014. (SCI )
  98. Kao FC, Tsai TT*, Chen LH, Lai PL, Fu TS, Niu CC, Ho NY, Chen WJ, Chang CJ: Symptomatic epidural hematoma after lumbar decompression surgery. Eur Spine J. Vol.24(2):348-57. Feb. 2015. (SCI )
  99. Tsai TT, Ho Natalie YJ, Fang HC, Lai PL, Niu CC, Chen LH, Chen WJ, S Pang JH*: Increased sulfatase 1 gene expression in degenerative intervertebral disc cells. Journal of Orthopaedic Research. Vol.33(3):312-317,2015. (SCI )
  100. Hsieh MK, Chen LH, Niu CC, Fu TS, Lai PL, Chen WJ＊: Combined anterior lumbar interbody fusion and instrumented posterolateral fusion for degenerative lumbar scoliosis: indication and surgical outcomes. BMC surgery, Vol.15:26, 2015. (SCI)
  101. Peng YS, Peng Sydeny, Tsai TT, Niu CC, Chu IM, Liao JC, Lai PL* (corresponding): Bone morphogenetic protein 2 gene delivery via polyethylene imine grafted chondroitin sulfate non-viral gene carrier. Formosan Journal of Musculoskeletal Disorders, Vol. 6:23-34, 2015.

榮譽 HONOR

  1. 中華民國骨科醫學會，【優秀論文獎佳作】，賴伯亮。The Role of Supraspinatous Ligament Integrity on Adjacent Segment Instability after Laminectomy – a Biomechanical Study in Porcine Model. Oct 25,2003.
  2. 生物醫學工程科技研討會，【口頭論文競賽優等】，李彥震，陳力輝，賴伯亮，戴金龍。PMMA骨水泥機械性質調控應用於椎體整形術之生物力學評估。Aug 20,2011.
  3. 第十七届生化工程研討會，【口頭論文優勝】，洪鼎惟，賴伯亮，朱一民。新型聚酸酐複合骨修復替代物研究。Jun 17, 2012.
  4. 中華民國骨科醫學會，【優秀論文基礎組第一名】，賴伯亮。Validation of polyanhydride and grafted hydroxyapatite composites as bone substitutes. Oct 27, 2012.
  5. 中華民國生物醫學工程創意競賽，【雅博科技獎】，朱一民，賴伯亮，洪鼎惟，劉倉豪，賴志騰。聚酸酐／氫氧基磷灰石複合材料用於硬骨組織修復之技術與應用。Nov 18, 2012.
  6. 國際生物力學研討會暨台灣生物力學年度學術研討會，【大會壁報論文優等獎第三名】，李柏誼，賴伯亮，戴金龍。利用小面關節植入物小面關節骨釘椎弓骨釘及脊突間固定器進行腰椎後位穩定手術的生物力學比較。Nov 23, 2012.
  7. 中華民國生醫材料及藥物制放年會暨國科會醫工學門成果發表會，【口頭論文組 佳作】，賴伯亮。利用聚乙二醇/聚乳酸/芳香族聚酸酐溫感性水膠包覆抗生素於藥物輸送系統之研究。May 05,2013.
  8. 第18屆生物技術暨生物工程研討會，【英文口頭報告優勝】，賴伯亮。The influences of polycaprolactone-grafted nanoparticles on the properties of polycaprolactone composites with enhanced osteoconductivity. Jun 28,2013.
  9. 2013年第九屆烏克蘭國際發明展，【金牌獎】，洪鼎惟，賴伯亮，朱一民。A novel biodegradable composite bone screw as in vivo implant. Sep 26-28, 2013.
  10. 2013年台灣創新發明競賽，【金牌獎】，洪鼎惟，古菀霖，陳翔麟，賴伯亮，朱一民。新穎性智慧水膠應用於體內感染治療之發明。Nov 09, 2013.

出版 TEXTBOOK CHAPTERS:

  1. Lai PL, Chen WJ: "Nonsurgical Treatment of Spinal Deformities" Chapter 49, P635-643；Daniel H. Kim., Randal R. Betz., Stephen L. Huhn., Peter O. Newton, Surgery of the Pediatric Spine, Thieme. (2008)

專利 PATENTS

  1. 戴金龍, 陳文哲, 賴伯亮, 陳文斌, 謝邦鑫, 李柏成, 陳世豪。可調高度式人工椎間盤。新型第M311407號(A61F-002/44) 。2007/5~2016/11
  2. 陳力輝, 戴金龍, 陳文哲, 賴伯亮。骨水泥注射器之輔助壓擠裝置。新型第M346407號(A61B-017/92)。2008/12/11~2018/5/15
  3. 何志傑,賴伯亮, 張順雄, 鄭遠東, 魏堂育。可調式壓力襯墊式脊椎側彎背架裝置。新型第M347926號(A61F-005/01)。2009/1/1~2018/6/12。
  4. 陳力輝, 戴金龍, 賴伯亮, 陳文哲。多方向性骨泥灌注中空骨釘。新型第M395455號。2011/1/1~2020/7/12。
  5. Ya-Jen Yu, Chin-Fu Chen, Tsai-Yu Lin, Shao-Jen Yeh, Shian-Yih Wang, Po-Liang Lai. Biodegradable copolymer and thermosensitive material. US, Patent No: US 7,884,142 B2. & US 8,309,623 B2
  6. 彭申桦、沈欣欣、杨良友、谢孟佑、李佩珊、余惟琳、林才佑、赖伯亮、孙瑞升、张至宏、林溢泓：治疗骨疾病的温度敏感性组合物；大陸發明專利201110182361. (授權公告日：2012/1/11)
  7. Shen-Hsin Peng, Hsin-Hsin Shen, Liang-Yo Yang, Meng-Yow Hsieh, Pei-Shan Li, Wei-Lin Yu, Tsai-Yu Lin, Po-Liang Lai, Jui-Sheng Sun, Chih-Hung Chang, Yi-Hung Lin. Thermal responsive composition for treating bone diseases. Patent application publication. Pub. No: 13172776  (Pub. Date: Jan.12, 2012).
  8. 游雅任、陳進富、林才祐、葉紹任、王先毅、賴伯亮。溫度敏感性材料；中華民國發明專利第I388591號。2013/3/11~2028/10/27。

PRESENTATION

  1. Gouty os trigonum - a case report. Poster, Orthopaedic Association ROC, Oct 18, 1996.
  2. Clinical and radiographic results of PCA total knee arthroplasty. Chang Gung Memorial Hospital 20th Year Anniversary, Taoyuan. Dec 6, 1996.
  3. A comparison of osteonecrosis and osteoarthritis treated with uncemented total hip arthroplasty. Annual Congress of the Orthopaedic Association ROC, Oct 3, 1997.
  4. Adjacent instability after pedicle screw fixation. Annual Congress of the Orthopaedic Association ROC, Oct 3, 1997.
  5. Degenerative lumbar scoliosis. Seasonal Congress of Spine Society ROC, Aug 1, 2000.
  6. Surgical treatment for adjacent instability. Annual Congress of Spine Society ROC, Apr 8, 2000.
  7. The effect of sagittal alignment on adjacent instability after lumbar instrumentation – A biomechanical study of lumbar vertebra in porcine model. The 44th Congress of Taiwan Orthopaedic Association. Apr 20, 2003.
  8. The role of supraspinatous ligament integrity on adjacent segment instability after lumbar instrumentation and laminectomy – A biomechanical study in porcine model. Annual Congress of Orthopaedic Association, Taiwan Oct 25, 2003.
  9. Preliminary result of segmental pedicle screw instrumentation for the treatment of adolescent idiopathic scoliosis. Annual Congress of Taiwan Orthopaedic Association, Oct 25, 2003.
  10. The role of posterior complex integrity on adjacent segment instability after lumbar instrumentation and laminectomy – A biomechanical study in porcine model. First Asian Pacific Conference on Biomechanics in Osaka, Japan. Mar 28, 2004.
  11. Relation between laminectomy and development of adjacent segment instability after lumbar fusion with pedicle fixation. The 12th Annual Conference of Taiwan Spine Society. Tainan, Taiwan. Apr 10, 2004.
  12. Unipedicular percutaneous vertebroplasty for treating compression fracture with intraosseous vacuum cleft. The 46th Congress of Taiwan Orthopedic Association. Taichung, Taiwan. Apr 24, 2004.
  13. Unipedicular percutaneous vertebroplasty. 14th Triennial Congress of Asia Pacific Orthopaedic Association. Kuala Lumpur, Malaysia. Sep 6, 2004.
  14. The effect of sagittal alignment on adjacent joint mobility after lumbar pedicle fixation. 14th Triennial Congress of Asia Pacific Orthopaedic Association. Kuala Lumpur, Malaysia. Sep 9, 2004.
  15. Delayed massive pleural effusion after scoliosis correction and thoracoplasty. Autumn Meeting of Taiwan Spine Society. 49th Annual Meeting of Taiwan Orthopaedic Association. Taipei, Taiwan. Oct 29, 2005.
  16. Delayed massive pleural effusion after scoliosis correction and thoracoplasty. 6th Combined Congress of the APOA Spine and Paediatric Orthopaedic Section. Nov 27, 2005.
  17. Will the extent of laminectomy increase the development of adjacent segment instability after lumbar fusion? 6th Combined Congress of the APOA Spine and Paediatric Orthopaedic Section. Nov 27, 2005.
  18. Clinical experience in management of myelomatous vertebral compression fracture with percutaneous vertebroplasty. The 7th Combined Congress of the Spine and Pediatric Sections, APOA, Jeju, Korea. Jun 4-7, 2008.
  19. In-situ posterolateral fusion and fixation without decompression for treating adult spondylolytic spondylolisthesis. The Annual Meeting of Orthopaedic Association, R.O.C. Oct. 25-26, 2008.
  20. Thermal damage potential during vertebroplasty in treatment of fractured vertebrae 生物醫學工程年會及科技研討會, 長庚大學 Dec 12-13, 2008.
  21. Development of algorithm and software for automated scoliotic curve measurement. IEICE, National Taiwan University, R.O.C. Jan 19-21, 2009.
  22. Selective thoracic fusion for idiopathic scoliosis. 台灣脊椎微創醫學會, 義大醫院, 高雄. Oct 25, 2010.
  23. Cement leakage during vertebroplasty potentially cause thermal damage. The Combined Conference of 16th Triennial Congress of Asia Pacific Orthopaedic Association and 59th Annual Meeting of Taiwan Orthopaedic Association. R.O.C. Nov 4-7, 2010.
  24. Application of bio-glue mixed with hydroxyapatite and tricalcium phosphate as bone graft substitute. 16th Symposium of Young Asian Biochemical Engineers' Community (YABEC 2010) Chungli, Taiwan, Nov 20-22, 2010.
  25. Solution to thermal injury in vertebroplasty. 台灣脊椎外科醫學會，林口長庚醫院，桃園，Mar 19, 2011.
  26. Spontaneous lumbar reduction after selective thoracic fusion.中華骨科兩岸學術交流會議，台北榮民總醫院. Mar 26-27, 2011.
  27. Correlation of lumbar curve, rotation and forward flexibility in idiopathic scoliosis. 中華民國骨科醫學會，春季學術研討會，高雄長庚醫院，Apr 23, 2011.
  28. Correlation of lumbar curve, vertebral rotation and forward flexibility in idiopathic scoliosis. APOA Spine and Pediatric Section, Gifu, Japan. Jun 1-4, 2011.
  29. Biomechanical comparison of screw holding power for different pedicle screw cement augmentation techniques in severe osteoporosis. XXIII Congress of the International Society of Biomechanics (XXIII ISB), Brussels, Belgium, July 3-7, 2011.
  30. Application of thermosensitive hydrogel and ceramic as bone substitute. 台灣脊椎外科醫學會100年度秋季季會，義大醫院，高雄，Oct 01, 2011.
  31. Mixing ceramic and thermosensitive hydrogel as composite bone graft. 中華民國骨科醫學會100年度聯合學術研討會，台北榮民總醫院，Nov 29, 2011.
  32. Polyanhydride copolymer blending with bioceramic composite for bone healing. 11th Asian BioCeramics Symposium. Tsukuba, Japan. Dec 1-3, 2011.
  33. Development of novel composite bone graft with suitable mechanical strength and long durability. 中華民國骨科醫學會101年度第62次春季聯合學術研討會，新竹喜來登飯店，Apr 21, 2012.
  34. Biomechanical study of facet implant. 中華民國骨科醫學會101年度春季學術研討會，新竹喜來登飯店，Apr 21, 2012.
  35. Effect of mixing bioactive nanoceramics with a thermosensitive hydrogel as bone substitute. 2012 International Conference on Nanostructures, Nanomaterials and Nanoengineering. Quality Hotel, Singapore. Oct 6-7, 2012.
  36. Validation of polyanhydride and grafted hydroxyapatite composites as bone implants. 中華民國骨科醫學會101年度第63次聯合學術研討會，台北南港展覽館，Oct 27, 2012. 【基礎研究組第一名】
  37. 利用小面關節植入物小面關節骨釘椎弓骨釘及脊突間固定器進行腰椎後位穩定手術的生物力學比較，2012國際生物力學研討會暨台灣生物力學年度學術研討會，台北國立陽明大學， Nov 23, 2012.
  38. 骨水泥冷卻處理可延長椎體整形術的操作時間，2012國際生物力學研討會暨台灣生物力學年度學術研討會，台北國立陽明大學，Nov 23, 2012.
  39. Application of scoliometer for predicting scoliotic curvature. 台灣脊椎外科醫學會102年度大會暨學術研討會，花蓮慈濟大學， Mar 23, 2013.
  40. The influences of polycaprolactone-grafted nanoparticles on the properties of polycaprolactone composites with enhanced osteoconductivity. 2013第18屆生物技術暨生物工程研討會, 國立虎尾科技大學，Jun 28, 2013. 【英文口頭報告優勝】
  41. Surgical outcomes of combined anterior and posterior spinal fusion for dystrophic neurofibromatosis. 中華民國骨科醫學會103年度第66次春季聯合學術研討會 台中榮總，Apr19, 2014.
  42. Non-viral gene transfection for bone morphogenetic protein express. 中華民國骨科醫學會103年度第66次春季聯合學術研討會，台中榮總，Apr 19, 2014.
  43. Spinal fusion with facetectomy bone chips and calcium sulfate for idiopathic scoliosis. 台灣脊椎外科醫學會104年度年會，福華國際文教會館，Mar 14, 2015.

INVITED SPEECH

  1. Evaluation of scoliosis and management in reference to adolescent idiopathic scoliosis. Kerala Orthopaedic Association, Kochi, India. Dec 5, 2004.
  2. Lumbar adjacent segment instability. Winter Meeting of Taiwan Spine Society. Tong’s Hospital, Taichung, Taiwan. Jan 8, 2005.
  3. Evaluation of scoliosis and management in reference to adolescent idiopathic scoliosis. Instructional Course. Datong, Shandong, China. Mar 27, 2005.
  4. 脊椎手術之術後背架之運用 台灣義肢裝具學會 台北榮民總醫院身障重建中心 Mar 11-12, 2006.
  5. Non-surgical treatment of spinal deformities. Annual Meeting of Taiwan Spine Society. Taipei, Taiwan, Apr 15, 2006.
  6. 胸椎椎弓螺釘固定治療脊椎側彎,中華骨科學術交流會議, 童綜合醫院, 沙鹿 Jul 15, 2006.
  7. Brace treatment of idiopathic scoliosis. AO course, Tainan, Taiwan, Sep 9, 2006.
  8. Adolescent Idiopathic Scoliosis. Taiwan Pediatric Orthopaedic Society, Taipei, Oct 28, 2006.
  9. Literature review, symposium of spinal osteoporotic compression fracture. 2007 台灣脊椎微創醫學會季會, 義大醫院, 高雄 Jan 13, 2007.
  10. Degenerative lumbar scoliosis. AO Spine Master Course, Taipei, Taiwan Oct 14, 2007.
  11. Severe scoliosis: strategy of surgical treatment. AO Spine Master Course, Taipei, Taiwan, Oct 14, 2007.
  12. Neuromuscular scoliosis: treatment strategy for non-ambulatory patients. AO Spine Master Course, Taipei, Taiwan, Oct 14, 2007.
  13. Application of pedicle screw in T-spine. 高級脊椎手術技術研討會, 台灣脊椎外科醫學會, 台北榮民總醫院,Sep 21, 2008.
  14. 脊柱側彎的手術治療, 財團法人臺灣基督教會門諾醫院醫療復健輔具中心, Dec 6, 2009.
  15. 脊柱側彎的治療, 財團法人臺灣基督教會門諾醫院醫療復健輔具中心, Nov 20, 2010.
  16. Biology of spinal fusion. 台灣脊椎外科醫學會101年住院醫師研習營，台北新店慈濟，Dec 22, 2012.
  17. Treatment of scoliosis – surgeons’ perspective. 台灣義肢裝具學會暨台灣人工肢體及輔具研究學會102年度會員大會暨聯合學術研討會- Multidisciplinary Management for Scoliosis. 桃園長庚醫院, Dec 7, 2013.
  18. Selective thoracic fusion for idiopathic scoliosis. 2013中華民國骨科醫學會桃竹苗月會, 桃園敏盛綜合醫院, Oct 19, 2013.

媒體報導

  1. 2008年10月16日，蘋果日報「騎單車處方，治療脊椎狹窄症」
  2. 2010年1月4日，蘋果日報「脊椎側彎，影響心肺功能」
  3. 2011年4月9日，國立教育電台校園健康筆記「脊椎側彎」


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