學歷

1985 中山醫學院醫學系醫學士

經歷

1999-2001 美國加州大學舊金山分校 腦瘤研究中心醫師研究員

2008-2012 林口長庚紀念醫院 腦腫瘤神經外科主任

2012-2014 林口長庚紀念醫院 神經外科主任

2012-2017 長庚大學 醫學系助理教授

2013-2020 林口長庚紀念醫院 外科部副主任

2017-2020 長庚大學 醫學系副教授

2017-2019 台灣神經腫瘤學 學會理事長

2019 亞洲神經腫瘤學會 研討會會主席

2020-2022 台灣神經外科 醫學會秘書長

現任

2020-迄今 新北市立土城醫院 副院長

2020-迄今 長庚大學 醫學系教授

2020-迄今 林口長庚紀念醫院 神經科學研究中心主任

獎項

2014 徐千田癌症研究傑出獎

2014 台灣生醫暨新農業產業選秀大賽潛力新秀獎

2015 長庚大學優良教師

2015 第十二屆國家新創獎

2016 國家衛生研究院傑出創新研究計畫

2017 科技部105年度傑出技術移轉貢獻獎

2018 長庚醫學研究獎

2019 第十六屆國家新創獎

2021 2021年台灣醫療典範獎

2021 第十八屆國家新創獎

論文篇數

國內外期刊論文：181篇

2010年一篇論文刊在權威的《美國國家科學院院刊》，該院刊還以專文推崇為「研究腦瘤治療的重要里程碑」。《美國化學雜誌》直指台灣這項創新研究，為腦瘤治療帶來重大突破。

國際醫療經驗

曾經提供來自歐美地區的腹主動脈瘤病患之低侵襲性主動脈支架治療，復原狀況良好，並提供完整追蹤。

1. Chen KT, Wei KC, Liu HL*. Theranostic Strategy of Focused Ultrasound Induced Blood-Brain Barrier Opening for CNS Disease Treatment. Frontiers in Pharmacology. 2019 Feb; 10: 86. (SCI; IF2020=5.810; Pharmacology & pharmacy 39/275) (Review)
2. Pang HH, Chen PY, Wei KC, Huang CW, Shiue YL, Huang CY*, Yang HW*. Convection-Enhanced Delivery of a Virus-Like Nanotherapeutic Agent with Dual-Modal Imaging for Besiegement and Eradication of Brain Tumors. Theranostics. 2019 Feb; 9(6): 1752–1763. (SCI; IF2020=11.556; Medicine, research & experimental 9/140)
3. Toh CH*, Liau CT, Wei KC, Castillo M. Baseline multicentric tumors, distant recurrences and leptomeningeal dissemination predict poor survival in patients with recurrent glioblastomas receiving bevacizumab. Journal of Neuro-Oncology. 2019 Mar; 142(1): 149-159 (SCI; IF2020=4.130; Clinical neurology 66/208)
4. Pang HH, Huang CY , Chou YW , Lin CJ , Zhou ZL , Shiue YL , Wei KC* , Yang HW*. Bioengineering fluorescent virus-like particle/RNAi nanocomplexes act synergistically with temozolomide to eradicate brain tumors. Nanoscale. 2019 Apr; 11(17): 8102-8109. (SCI; IF2020=7.790; Physics, applied 23/160) (co-corresponding author)
5. Wang YC, Lee CC, Takami H, Shen S, Chen KT, Wei KC, Wu MH, Worrell G, Chen PY*. Awake craniotomies for epileptic gliomas: intraoperative and postoperative seizure control and prognostic factors. Journal of Neuro-Oncology. 2019 May; 142(3): 577-586. (SCI; IF2020=4.130; Clinical neurology 66/208)
6. Chang CW, Hsu PW, Wei KC, Chang CW, Fung HC, Hsih MS, Hsu WC, Ro LS, Chang CN, Wang JJ, Wu YR*, Chen ST*. CCM1 and CCM2 variants in patients with cerebral cavernous malformation in an ethnically Chinese population in Taiwan. Scientific Reports. 2019 Aug 27; 9: 12387. (SCI; IF2020=4.379; Multidisciplinary sciences 17/73)
7. Yeap MC, Tu PH, Liu ZH, Hsieh PC, Liu YT, Lee CY, Lai HY, Chen CT, Huang YC, Wei KC, Wu CT, Chen CC*. Long-Term Complications of Cranioplasty Using Stored Autologous Bone Graft, Three-Dimensional Polymethyl Methacrylate, or Titanium Mesh After Decompressive Craniectomy: A Single-Center Experience After 596 Procedures. World Neurosurgery. 2019 Aug; 128: e841-e850. (SCI; IF2020=2.104; Surgery 125/212)
8. Deng WC, Yan JL, Chuang CC, Wei KC, Chang CN, Wu CT, Chen HC, Wang CC, Tseng CK, Hsu PW*. Adjuvant Radiation Therapy Compared to Observation Alone for Postoperative Residual Non-functional Pituitary Adenomas. World Neurosurgery. 2019 Aug; 128: e1024-e1033. (SCI; IF2020=2.104; Surgery 125/212)
9. Yeap MC, Chen CC, Liu ZH, Hsieh PC, Lee CC, Liu YT, Yi-Chou Wang A, Huang YC, Wei KC, Wu CT, Tu PH*. Postcranioplasty seizures following decompressive craniectomy and seizure prophylaxis: a retrospective analysis at a single institution. Journal of Neurosurgery. 2019 Sep; 131(3): 936-940. (SCI; IF2020=5.115; Surgery 22/212)
10. Lin CJ, Lin CY, Lin YT, Huang CY, Wei KC, Chen JC, Lee-Chen GJ, Liu HL*. Microbubble-facilitated ultrasound pulsation promotes direct α-synuclein gene delivery. Biochemical and Biophysical Research Communications. 2019 Sep; 517(1): 77-83. (SCI; IF2020=3.375; Biophysics 30/72)
11. Lin CY, Tsai CH, Feng LY, Chai WY, Lin CJ, Huang CY, Wei KC, Yeh CK, Chen CM*, Liu HL*. Focused ultrasound-induced blood brain-barrier opening enhanced vascular permeability for GDNF delivery in Huntington's disease mouse model. Brain Stimulation. 2019 Sep-Oct; 12(5): 1143-1150. (SCI; IF2020=8.955; Clinical neurology 13/208)
12. Wang JC*, Karmakar RS, Lu YJ*, Chan SH, Wu MC, Lin KJ, Chen CK, Wei KC, Hsu YH. Miniaturized Flexible Piezoresistive Pressure Sensors: Poly(3,4-ethylenedioxythiophene):Poly(styrenesulfonate) Copolymers Blended with Graphene Oxide for Biomedical Applications. ACS Applied Materials & Interfaces. 2019 Sep; 11(37): 34305-34315. (SCI; IF2020=9.229; Materials science, multidisciplinary 44/335)
13. Ho YJ, Chu SW, Liao EC, Fan CH, Chan HL, Wei KC, Yeh CK*. Normalization of Tumor Vasculature by Oxygen Microbubbles With Ultrasound. Theranostics. 2019 Sep; 9(24): 7370-7383. (SCI; IF2020=11.556; Medicine, research & experimental 9/140)
14. Chen PY, Wu CYJ, Fang JH, Chen HC, Feng LY, Huang CY, Wei KC, Fang JY*, Lin CY*. Functional Change of Effector Tumor-Infiltrating CCR5+CD38+HLA-DR+CD8+ T Cells in Glioma Microenvironment. Frontiers in Immunology. 2019 Oct; 10: 2395 (SCI; IF2020=7.561; Immunology 24/162)
15. Chen CH¹, Chen PY, Lin YY, Feng LY, Chen SH, Chen CY, Huang YC, Huang CY, Jung SM, Chen LY, Wei KC¹*. Suppression of tumor growth via IGFBP3 depletion as a potential treatment in glioma. Journal of Neurosurgery. 2020 Jan; 132(1): 168-179. (SCI; IF2020=5.115; Surgery 22/212) (¹co-first author)
16. Liao WC, Liao CK, Tseng TJ, Ho YJ, Chen YR, Lin KH, Lai TJ, Lan CT, Wei KC, Liu CH*. Chondroitin Sulfate Synthase 1 Enhances Proliferation of Glioblastoma by Modulating PDGFRA Stability. Oncogenesis. 2020 Feb; 9(2): 9 (SCI; IF2020=7.485; Oncology 40/242)
17. Wu CY, Chen CH, Lin CY, Feng LY, Lin YC, Wei KC, Huang CY, Fang JY*, Chen PY*. CCL5 of glioma-associated microglia/macrophages regulates glioma migration and invasion via calcium-dependent matrix metalloproteinase-2. Neuro-Oncology. 2020 Feb; 22(2): 253-266. (SCI; IF2020=12.300; Clinical neurology 7/208)
18. Chen PA, Chen YC, Wei KC, Chen KT*. Awake Craniotomy for a Left Pan-Hippocampal Diffuse Low Grade Glioma in a Deaf-Mute Patient Using Sign Language. World Neurosurgery. 2020 Feb; 134: 629-634 (SCI; IF2020=2.104; Surgery 125/212) (case report)
19. Hsu YP, Li NS, Chen YT, Pang HH, Wei KC, Yang HW*. A serological point-of-care test for Zika virus detection and infection surveillance using an enzyme-free vial immunosensor with a smartphone. Biosensors & Bioelectronics. 2020 Mar; 151: 111960. (SCI; IF2020=10.618; Chemistry, analytical 3/83)
20. Yeh YC, Wei KC, Chen KT*. Transmastoid Presigmoid Retrolabyrinthine Approach for Removal of Pontine Cavernous Malformation: How I Do It. Acta Neurochirurgica. 2020 May; 162(5): 1131-1135. (SCI; IF2020=2.216; Surgery 119/212)
21. Chen KT, Lin YJ, Chai WY, Lin CJ, Chen PY, Huang CY, Kuo JS, Liu HL, Wei KC*. Neuronavigation-guided focused ultrasound (NaviFUS) for transcranial blood-brain barrier opening in recurrent glioblastoma patients: clinical trial protocol. Annals of Translational Medicine. 2020 Jun; 8(11): 673. (SCI; IF2020=3.932; Medicine, research & experimental 73/140)
22. Huang CW, Chang YH, Lee HH, Wu JY, Huang JX, Chung YH, Hsu ST, Chow LP, Wei KC, Huang FT*. Irisin, an exercise myokine, potently suppresses tumor proliferation, invasion, and growth in glioma. FASEB Journal. 2020 Jul; 34(7): 9678-9693. (SCI; IF2020=5.191; Biology 14/93)
23. Li NS, Chen YT, Hsu YP, Pang HH, Huang CY, Shiue YL, Wei KC*, Yang HW*. Mobile Healthcare System Based on the Combination of a Lateral Flow Pad and Smartphone for Rapid Detection of Uric Acid in Whole Blood. Biosensors & Bioelectronics. 2020 Sep; 164: 112309. (SCI; IF2020=10.618; Chemistry, analytical 3/83) (co-corresponding author)
24. Toh CH*, Castillo M, Wei KC, Chen PY. MRS as an Aid to Diagnose Malignant Transformation in Low-Grade Gliomas with Increasing Contrast Enhancement. American Journal of Neuroradiology. 2020 Sep; 41(9): 1592-1598. (SCI; IF2020=3.825; Radiology, nuclear medicine & medical imaging 40/134)
25. Hsu WL, Huang CY, Hsu YP, Hwang TL, Chang SH, Wang HYJ, Feng LY, Tzou SJ, Wei KC*, Yang HW*. On-skin glucose-biosensing and on-demand insulin-zinc hexamers delivery using microneedles for syringe-free diabetes management. Chemical Engineering Journal. 2020 Oct; 398: 125536. (SCI; IF2020=13.273; Engineering, chemical 4/143) (co-corresponding author)
26. Pang HH, Ke YC, Li NS, Chen YT, Huang CY, Wei KC*, Yang HW*. A new lateral flow plasmonic biosensor based on gold-viral biomineralized nanozyme for on-site intracellular glutathione detection to evaluate drug-resistance level. Biosensors & Bioelectronics. 2020 Oct; 165: 112325. (SCI; IF2020=10.618; Chemistry, analytical 3/83) (co-corresponding author)
27. Huang SH, Wang CC, Wei KC, Chang CN, Chuang CC, Chen HC, Lin YJ, Chen KT, Pai PC, Hsu PW*. Treatment of intracranial meningioma with single-session and fractionated radiosurgery: a propensity score matching study. Scientific Reports. 2020 Oct; 10(1): 18500. (SCI; IF2020=4.379; Multidisciplinary sciences 17/73)
28. Chen HY, Chuang CC, Chen HC, Wei KC, Chang CN, Liu ZH, Lee CC, Wang CC, Pai PC, Hsu PW*. Clinical outcomes of fractionated stereotactic radiosurgery in treating perioptic meningiomas and schwannomas: A single-institutional experience. Journal of Clinical Neuroscience. 2020 Nov; 81: 409-415. (SCI; IF2020=1.961; Clinical neurology 167/208)
29. Karmakar RS, Wang JC, Huang YT, Lin KJ, Wei KC, Hsu YH, Huang YC, Lu YJ*. Real-Time Intraoperative Pressure Monitoring to Avoid Surgically Induced Localized Brain Injury Using a Miniaturized Piezoresistive Pressure Sensor. ACS Omega. 2020 Nov; 5(45): 29342-29350. (SCI; IF2020=3.512; Chemistry, multidisciplinary 78/179)
30. Lin SS, Niu CC, Yuan LJ, Tsai TT, Lai PL, Chong KY, Wei KC, Huang CY, Lu ML, Yang CY, Ueng SWN*. Mir-573 regulates cell proliferation and apoptosis by targeting Bax in human degenerative disc cells following hyperbaric oxygen treatment. Journal of Orthopaedic Surgery and Research. 2021 Jan; 16(1): 16. (SCI; IF2020=2.359; Orthopedics 42/82)
31. Li YC, Chiu HY, Lin YJ, Chen KT, Hsu PW, Huang YC, Chen PY*, Wei KC. The Merits of Awake Craniotomy for Glioblastoma in the Left Hemispheric Eloquent Area: One Institution Experience. Clinical Neurology and Neurosurgery. 2021 Jan; 200: 106343. (SCI; IF2020=1.876; Surgery 141/212)
32. Chen KT, Chai WY, Lin YJ, Lin CJ, Chen PY, Tsai HC, Huang CY, Kuo JS, Liu HL*, Wei KC*. Neuronavigation-guided focused ultrasound for transcranial blood-brain barrier opening and immunostimulation in brain tumors. Science Advances. 2021 Feb; 7(6): eabd0772. (SCI; IF2020=14.136; Multidisciplinary sciences 5/73) (co-corresponding author)
33. Chen CH, Lin YJ, Lin YY, Lin CH, Feng LY, Chang IY, Wei KC, Huang CY*. Glioblastoma Primary Cells Retain the Most Copy Number Alterations That Predict Poor Survival in Glioma Patients. Frontiers in Oncology. 2021 Apr; 11: 621432. (SCI; IF2020=6.244; Oncology 62/242)
34. Lee CC, Wang YC, Liu YT, Huang YC, Hsu PW, Wei KC, Chen KT, Lin YJ, Chuang CC*. Incidence and Factors Associated with Postoperative Delayed Hyponatremia after Transsphenoidal Pituitary Surgery: A Meta-Analysis and Systematic Review. International Journal of Endocrinology. 2021 Apr; 2021: 6659152. (SCI; IF2020=3.257; Endocrinology & metabolism 98/145)
35. Ho YJ, Chang HC, Lin CW, Fan CH*, Lin YC, Wei KC, Yeh CK*. Oscillatory behavior of microbubbles impacts efficacy of cellular drug delivery. Journal of Controlled Release. 2021 May; 333: 316-327. (SCI; IF2020=9.776; Pharmacology & pharmacy 9/275)
36. Yan JL*, Toh CH, Ko L, Wei KC, Chen PY*. A Neural Network Approach to Identify Glioblastoma Progression Phenotype from Multimodal MRI. Cancers. 2021 May; 13(9): 2006. (SCI; IF2020=6.639; Oncology 51/242)
37. Kang Y, Wei KC, Toh CH*. Can We Predict Intraoperative Blood Loss in Meningioma Patients? Application of Dynamic Susceptibility Contrast-Enhanced Magnetic Resonance Imaging. Journal of Neuroradiology. 2021 Jun; 48(4): 254-258. (SCI; IF2020=3.447; Radiology, nuclear medicine & medical imaging 53/134)
38. Huang CW, Chuang CP, Chen YJ, Wang HY, Lin JJ, Huang CY, Wei KC, Huang FT*. Integrin α₂β₁-targeting ferritin nanocarrier traverses the blood-brain barrier for effective glioma chemotherapy. Journal of Nanobiotechnology. 2021 Jun; 19: 180 (SCI; IF2020=10.435; Biotechnology & applied microbiology 8/159)
39. Chen KT, Wei KC*, Liu HL*. Focused Ultrasound Combined with Microbubbles in Central Nervous System Applications. Pharmaceutics. 2021 Jul; 13(7): 1084. (SCI; IF2020=6.321; Pharmacology & pharmacy 29/275) (co-corresponding author) (Review article)
40. Fan CH¹, Wei KC¹, Chiu NH, Liao EC, Wang HC, Wu RY, Ho YJ, Chan HL, Wang TA, Huang YZ, Hsieh TH, Lin CH, Lin YC, Yeh CK*. Sonogenetic-Based Neuromodulation for the Amelioration of Parkinson's Disease. Nano Letters. 2021 Jul; 21(14): 5967-5976. (SCI; IF2020=11.189; Physics, applied 15/160) (¹co-first author)
41. Lin YJ, Wei KC, Chen PY, Lim M*, Hwang TL*. Roles of Neutrophils in Glioma and Brain Metastases. Frontiers in Immunology. 2021 Aug; 12: 701383. (SCI; IF2020=7.561; Immunology 24/162) (Review article)
42. Wong AM, Siow TY, Wei KC, Chen PY, Toh CH*, Castillo M. Prediction of Malignant Transformation of WHO II Astrocytoma Using Mathematical Models Incorporating Apparent Diffusion Coefficient and Contrast Enhancement. Frontiers in Oncology. 2021 Sep 29; 11: 744827. (SCI; IF2020=6.244; Oncology 62/242)
43. Tsai HC, Wei KC, Chen PY, Huang CY, Chen KT, Lin YJ, Cheng HW, Chen YR, Wang HT*. Valproic Acid Enhanced Temozolomide-Induced Anticancer Activity in Human Glioma Through the p53-PUMA Apoptosis Pathway. Frontiers in Oncology. 2021 Oct 1; 11: 722754. (SCI; IF2020=6.244; Oncology 62/242)
44. Wei KC, Lin YC, Chen CH, Chu YH, Huang CY, Liao WC, Liu CH*. Fucosyltransferase 8 modulates receptor tyrosine kinase activation and temozolomide resistance in glioblastoma cells. American Journal of Cancer Research. 2021 Nov; 11(11): 5472-5484. (SCI; IF2020=6.166; Oncology 64/242)
45. Wang HL, Yeh TH, Huang YZ, Weng YH, Chen RS, Lu CS, Wei KC, Liu YC, Chen YL, Chen CL, Chen YJ, Lin YW, Hsu CC, Chiu CH, Chiu CC*. Functional variant rs17525453 within RAB35 gene promoter is possibly associated with increased risk of Parkinson's disease in Taiwanese population. Neurobiology of Aging. 2021 Nov; 107: 189-196. (SCI; IF2020=4.673; Geriatrics & gerontology 14/53)
46. Wei KC*, Hsu PW, Tsai HC, Lin YJ, Chen KT, Toh CH, Huang HL, Jung SM, Tseng CK, Ke YX. Safety and tolerability of asunercept plus standard radiotherapy/temozolomide in Asian patients with newly-diagnosed glioblastoma: a phase I study. Scientific Reports. 2021 Dec; 11: 24067. (SCI; IF2020=4.379; Multidisciplinary sciences 17/73)
47. Lin SY, Tsan DL, Chuang CC, Yang CC, Pai PC, Wang CL, Wu YM, Lee CC, Lin CH, Wei KC, Chou WC*. Oncological Outcomes After Hippocampus-Sparing Whole-Brain Radiotherapy in Cancer Patients With Newly Diagnosed Brain Oligometastases: A Single-Arm Prospective Observational Cohort Study in Taiwan. Frontiers in Oncology. 2022 Jan; 11: 784635. (SCI; IF2020=6.244; Oncology 62/242)
48. Yeap MC, Chen CC, Chen CT, Liu ZH, Wu CT, Hsieh PC, Lai HY, Wang YC, Chang TW, Lee CC, Liu YT, Huang YC, Wei KC, Tu PH*. Predictive Value of Swab Cultures for Cryopreserved Flaps During Delayed Cranioplasties. World Neurosurgery. 2022 Jan; 157: e173-e178. (SCI; IF2020=2.104; Surgery 125/212)
49. Yen HC*, Chen BS, Yang SL, Wu SY, Chang CW, Wei KC, Hsu JC, Hsu YH, Yen TH, Lin CL*. Levels of Coenzyme Q₁₀ and Several COQ Proteins in Human Astrocytoma Tissues Are Inversely Correlated with Malignancy. Biomolecules. 2022 Feb; 12(2): 336. (SCI; IF2020=4.879; Biochemistry & molecular biology 96/295)
50. Tsai HC, Wei KC, Chen PY, Huang CY, Chen KT, Lin YJ, Cheng HW, Huang CH, Wang HT*. Receptor-Interacting Protein 140 Enhanced Temozolomide-Induced Cellular Apoptosis Through Regulation of E2F1 in Human Glioma Cell Lines. Neuromolecular Medicine. Early published online on 1 Jun 2021. doi: 10.1007/s12017-021-08667-x. (SCI; IF2020=3.843; Neurosciences 127/273)